TP53 and Beta-catenin mutations in liver tumours

<p class="MsoNormal"><span style="font-size: 10pt; font-family: QuorumITCbyBT-Book">HBV and HCV play key roles in the etiopathogenesis of Hepatocellular carcinoma (HCC).Studies mostly based on cases from Western countries suggest distinct genetic pathways of carcinogenesis involving either TP53 or CTTNB1 mutations.Inappropriate reactiva

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Gender-Oriented Education: A New Approach to Gender Equity

The twentieth century can be considered the century of gender approaches.From extremist and one-sided movements to moderate and neutral schools of thought about gender, which have surrounded the last century and all of them had originated in achieving gender justice, but each has taken a different approach as a different definition of equity.The cu

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Body-Packing: A Rare Diagnosis to Keep in Mind

Body packing was first described in 1973 and refers to the intracorporeal concealment of illegal drugs, which are swallowed or placed in anatomical cavities and/or body orifices.The body packer can be asymptomatic or can have signs of systemic drug toxicity (neurological, cardiac, abdominal, renal and cutaneous) due to rupture of the packet(s) or s

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A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability

Abstract Background Fascin-1 is an actin crosslinking protein that is important for the assembly of cell protrusions in neurons, skeletal and tuner signal wire smooth muscle, fibroblasts, and dendritic cells.Although absent from most normal adult epithelia, fascin-1 is upregulated in many human carcinomas, and is associated with poor prognosis beca

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Acute Respiratory Barrier Disruption by Ozone Exposure in Mice

Ozone exposure causes irritation, airway hyperreactivity (AHR), inflammation Body Brush of the airways, and destruction of alveoli (emphysema), the gas exchange area of the lung in human and mice.This review focuses on the acute disruption of the respiratory epithelial barrier in mice.A single high dose ozone exposure (1 ppm for 1 h) causes first a

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